Albumin-Globulin (A/G) Ratio Calculator
Enter your serum albumin and total protein values to compute the albumin-to-globulin (A/G) ratio and see whether it falls within the normal reference range of 1.0–2.0.
g/dL
g/dL
Normal (1.0–2.0)
- 1
Globulin
7.5 − 4 = 3.5Globulin = total protein − albumin. - 2
A/G Ratio
4 ÷ 3.5 = 1.14
How does this calculator work?
Globulin (g/dL) = Total Protein − Albumin. A/G Ratio = Albumin ÷ Globulin. The normal range is 1.0–2.0. A low ratio may indicate liver disease or elevated immune globulins; a high ratio may reflect low globulin. Enter albumin and total protein from your blood panel to get the ratio instantly — always discuss results with your doctor.
Formula
How this is calculated
The albumin-globulin (A/G) ratio compares two classes of proteins found in blood serum. Albumin is the most abundant plasma protein — made by the liver — and serves as a carrier for hormones, fatty acids, and drugs while also maintaining osmotic pressure. Globulins are a heterogeneous group that includes clotting factors, enzymes, antibodies (immunoglobulins), and transport proteins like haptoglobin and transferrin.
Because a standard comprehensive metabolic panel (CMP) reports both total protein and albumin but not globulin separately, globulin must be derived: Globulin = Total Protein − Albumin. The A/G ratio then shows which fraction dominates. A normal ratio is roughly 1.0–2.0 (some labs use 1.1–2.1); values vary slightly by laboratory and assay. A low A/G ratio (< 1.0) may indicate reduced albumin production (liver disease, malnutrition) or elevated globulins (chronic infection, autoimmune disease, multiple myeloma). A high A/G ratio (> 2.0) is less common and can reflect low globulin production.
This calculator performs only the arithmetic step. Interpretation always requires your doctor because lab reference ranges differ between laboratories, results must be interpreted alongside clinical history, and a single out-of-range value is rarely diagnostic by itself.
Frequently asked questions
Most laboratories consider 1.0–2.0 a normal A/G ratio (some use 1.1–2.1). The ratio reflects the balance between albumin (made by the liver) and globulins (produced by the liver and immune system). Values outside this range should be evaluated by a clinician in context with other findings.
A ratio below 1.0 most often means albumin is low (liver disease, nephrotic syndrome, malnutrition) or globulins are elevated (chronic inflammation, autoimmune conditions, infections, multiple myeloma). The clinical context and other labs — such as liver enzymes, creatinine, and CBC — guide diagnosis.
Yes — most CMP panels report total protein and albumin. Subtract albumin from total protein to get the globulin fraction: Globulin = Total Protein − Albumin. Some panels also order serum protein electrophoresis (SPEP) to separate globulin subtypes (alpha, beta, gamma) for more specific diagnoses.
TG we-Calculate Editorial Team. (2026). Albumin-Globulin (A/G) Ratio Calculator [Online calculator]. TG we-Calculate. https://we-calculate.com/calculator/albumin-globulin-ratio-calculator
TG we-Calculate Editorial Team. "Albumin-Globulin (A/G) Ratio Calculator." TG we-Calculate. 2026. https://we-calculate.com/calculator/albumin-globulin-ratio-calculator.
TG we-Calculate Editorial Team, "Albumin-Globulin (A/G) Ratio Calculator," TG we-Calculate, 2026. [Online]. Available: https://we-calculate.com/calculator/albumin-globulin-ratio-calculator
@misc{wecalculate_albumin_globulin_ratio_calculator, title = {Albumin-Globulin (A/G) Ratio Calculator}, author = {{TG we-Calculate Editorial Team}}, howpublished = {\url{https://we-calculate.com/calculator/albumin-globulin-ratio-calculator}}, year = {2026}, note = {TG we-Calculate} }
Did this calculator help you?