MIPI Calculator — Mantle Cell Lymphoma Prognostic Index
Compute the Mantle Cell Lymphoma International Prognostic Index (MIPI) from age, ECOG performance status, LDH/ULN ratio and leukocyte count, then see the corresponding low/intermediate/high-risk classification.
years
ECOG Performance Status
U/L
U/L
/μL
Mantle Cell Lymphoma International Prognostic Index
- 1
Age term
0.03535 × 65 = 2.2978 - 2
ECOG term
ECOG 0 ≤ 1 → 0 = 0 - 3
LDH / ULN term
1.367 × log₁₀(200 ÷ 240) = -0.1082 - 4
WBC term
0.9393 × log₁₀(6,000) = 3.5488 - 5
MIPI score
2.2978 + 0 + -0.1082 + 3.5488 = 5.738
How does this calculator work?
MIPI = 0.03535 × age + 0.6978 × (ECOG > 1) + 1.367 × log10(LDH/ULN) + 0.9393 × log10(WBC/μL). Scores < 5.7 = low risk, 5.7–6.2 = intermediate, ≥ 6.2 = high risk, with historical 5-year overall survival of ~60%, ~35% and ~20% respectively. All results require clinical interpretation.
Formula
How this is calculated
The MIPI (Mantle Cell Lymphoma International Prognostic Index) was developed by Hoster et al. (Haematologica, 2008) from a multivariate analysis of 455 MCL patients treated in the German Low Grade Lymphoma Study Group trials. The four independent predictors are: patient age (linear, continuous), ECOG performance status (binary — 0 if PS ≤ 1, 0.6978 if PS ≥ 2), the ratio of serum LDH to the laboratory upper limit of normal on a log10 scale, and the peripheral leukocyte count in /μL on a log10 scale.
Cut-off scores divide patients into three risk groups: low risk (MIPI < 5.7, ≈ 60% 5-year overall survival in the derivation cohort), intermediate risk (5.7 ≤ MIPI < 6.2, ≈ 35% OS), and high risk (MIPI ≥ 6.2, ≈ 20% OS). These survival figures are historical estimates from patients treated in 1998–2006 and may not reflect outcomes with modern targeted therapies such as BTK inhibitors or CAR-T cells.
WBC is entered in cells per μL (e.g. 6 000 for 6 × 10³/μL). If your lab reports in 10⁹/L, multiply by 1 000. The LDH ULN is lab-specific — enter your institution's stated upper limit (commonly 240 U/L). Results must be interpreted by a qualified haematologist in the context of full clinical, pathological and imaging findings.
Frequently asked questions
A MIPI of 5.9 falls in the intermediate-risk group (5.7–6.2). The original cohort showed approximately 35% 5-year overall survival in this group. Discuss the implications with your haematologist, who will consider additional factors and treatment options.
Enter WBC in cells per μL (e.g. 6 000 for a count of 6.0 × 10³/μL or 6.0 × 10⁹/L). If your lab report shows 6.0 × 10⁹/L, multiply by 1 000 to get 6 000/μL.
Yes — the sMIPI replaces the continuous LDH ratio with a binary elevated/normal flag, making mental arithmetic easier. This calculator implements the full continuous MIPI, which has slightly better discriminatory power. The two scores usually give the same risk-group classification.
Also known as
TG we-Calculate Editorial Team. (2026). MIPI Calculator — Mantle Cell Lymphoma Prognostic Index [Online calculator]. TG we-Calculate. https://we-calculate.com/calculator/mipi-calculator
TG we-Calculate Editorial Team. "MIPI Calculator — Mantle Cell Lymphoma Prognostic Index." TG we-Calculate. 2026. https://we-calculate.com/calculator/mipi-calculator.
TG we-Calculate Editorial Team, "MIPI Calculator — Mantle Cell Lymphoma Prognostic Index," TG we-Calculate, 2026. [Online]. Available: https://we-calculate.com/calculator/mipi-calculator
@misc{wecalculate_mipi_calculator, title = {MIPI Calculator — Mantle Cell Lymphoma Prognostic Index}, author = {{TG we-Calculate Editorial Team}}, howpublished = {\url{https://we-calculate.com/calculator/mipi-calculator}}, year = {2026}, note = {TG we-Calculate} }
Did this calculator help you?