TIMI Risk Score for UA/NSTEMI Calculator
The TIMI (Thrombolysis in Myocardial Infarction) Risk Score for UA/NSTEMI assigns 1 point for each of 7 clinical variables; the total (0–7) estimates the likelihood of death, MI, or urgent revascularisation within 14 days.
Age ≥ 65 years
≥ 3 CAD risk factors
Prior coronary stenosis ≥ 50%
Aspirin use in past 7 days
Severe angina events (past 24 h)
ST deviation on ECG
Positive cardiac marker
Score 0–7; higher = greater 14-day event risk
- 1
Patient history criteria
age≥65 (0) + ≥3 CAD risks (0) + known CAD (0) = 0 - 2
Presentation criteria
ASA (0) + events (0) + ECG (0) + marker (0) = 0 - 3
TIMI UA/NSTEMI score
0 + 0 = 0
How does this calculator work?
The TIMI UA/NSTEMI score sums 7 binary criteria (each 0 or 1): age ≥ 65, ≥ 3 CAD risk factors, known CAD ≥ 50%, ST deviation on ECG, ≥ 2 anginal events in 24 h, ASA in past 7 days, and positive cardiac marker. Score 0–2 = low risk (~5%), 3–4 = intermediate (~13–20%), 5–7 = high risk (26–41%) 14-day event rate.
Formula
How this is calculated
The TIMI UA/NSTEMI score was derived from the TIMI-11B trial (Antman et al., JAMA 2000) in patients presenting with chest pain and non-ST-elevation ACS. Seven clinical variables are each worth 1 point: age ≥ 65; presence of ≥ 3 traditional CAD risk factors; known coronary stenosis ≥ 50%; ST-segment deviation ≥ 0.5 mm on the presenting ECG; ≥ 2 anginal events in the prior 24 hours; ASA use in the prior 7 days (a surrogate for existing vascular disease); and a positive cardiac biomarker (troponin or CK-MB). The score is the simple integer sum, ranging from 0 to 7.
The 14-day event rate (composite of all-cause death, new or recurrent MI, and urgent revascularisation) rises steeply with the score: roughly 5% at 0–1, 8% at 2, 13% at 3, 20% at 4, 26% at 5, and about 41% at 7. Scores ≤ 2 are generally classified as low risk, 3–4 as intermediate, and ≥ 5 as high risk, with guidelines recommending more aggressive early invasive management at higher scores.
This calculator assumes a hospital-based clinical presentation. The TIMI score is one of several validated tools for ACS risk stratification (others include GRACE and HEART); no single score replaces full clinical assessment. Event rates cited are from the original 2000 validation cohort and may differ in contemporary practice.
Frequently asked questions
ASA use in the 7 days before presentation is a surrogate marker of chronic cardiovascular disease rather than aspirin being harmful. Patients already on aspirin typically have pre-existing vascular disease and therefore face higher baseline event risk — it's a confounder variable, not a causal one.
Current AHA/ACC guidelines suggest considering early invasive management for TIMI scores of 3 or higher, particularly scores ≥ 5. However, the TIMI score must be interpreted alongside overall clinical presentation, haemodynamic stability, and patient preferences. Always defer to the treating cardiologist.
GRACE uses continuous variables (age, heart rate, blood pressure, creatinine) and provides a probability estimate over a broader risk range; GRACE generally has superior discrimination (AUC ~0.83 vs ~0.65 for TIMI). TIMI is simpler and faster to compute at the bedside. Many centres use both for complementary risk stratification.
Also known as
TG we-Calculate Editorial Team. (2026). TIMI Risk Score for UA/NSTEMI Calculator [Online calculator]. TG we-Calculate. https://we-calculate.com/calculator/timi-ua-nstemi-calculator
TG we-Calculate Editorial Team. "TIMI Risk Score for UA/NSTEMI Calculator." TG we-Calculate. 2026. https://we-calculate.com/calculator/timi-ua-nstemi-calculator.
TG we-Calculate Editorial Team, "TIMI Risk Score for UA/NSTEMI Calculator," TG we-Calculate, 2026. [Online]. Available: https://we-calculate.com/calculator/timi-ua-nstemi-calculator
@misc{wecalculate_timi_ua_nstemi_calculator, title = {TIMI Risk Score for UA/NSTEMI Calculator}, author = {{TG we-Calculate Editorial Team}}, howpublished = {\url{https://we-calculate.com/calculator/timi-ua-nstemi-calculator}}, year = {2026}, note = {TG we-Calculate} }
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