MME Calculator — Morphine Milligram Equivalents
Convert an opioid dose to morphine milligram equivalents (MME/day) using CDC 2022 clinical conversion factors — helps compare opioid regimens and assess dose against CDC risk thresholds.
Opioid
mg/day
Oral morphine milligram equivalents per day — CDC 2022 factors
- 1
Conversion factor
CDC 2022 factor for Oxycodone = 1,5 MME/mg - 2
MME per day
20 × 1,5 = 30
Kako radi ovaj kalkulator?
MME/day = daily opioid dose × CDC 2022 factor. Key factors: morphine 1.0, oxycodone 1.5, hydromorphone 4.0, tramadol 0.1, fentanyl patch 2.4 per mcg/h, methadone 4–12 (dose-dependent). CDC caution thresholds: 50 MME/day (increased risk) and 90 MME/day (high risk). All dosing decisions must be confirmed with a clinician.
Formula
How this is calculated
Different opioids vary widely in potency. Morphine Milligram Equivalents (MME) create a standardised "common currency" so clinicians can compare doses across agents. The CDC 2022 Clinical Practice Guideline publishes conversion factors — MME per milligram of drug — which this calculator applies: MME/day = daily dose × factor.
For oral morphine the factor is 1.0 by definition; oxycodone is 1.5×; hydromorphone 4.0×; and tramadol only 0.1×. Fentanyl transdermal patches are measured in mcg per hour, not mg per day; the CDC factor of 2.4 MME per mcg/h converts patch strength directly (a 25 mcg/h patch gives 25 × 2.4 = 60 MME/day). Methadone is unique: its potency increases with dose because of tissue accumulation, so the CDC applies a step-wise factor (4 MME/mg for ≤ 20 mg/day, rising to 12 MME/mg for > 60 mg/day).
The risk meter reflects CDC 2022 thresholds: doses above 50 MME/day warrant increased clinical vigilance; above 90 MME/day the CDC recommends careful reassessment of risks and benefits. These are population-level benchmarks, not absolute limits — individual clinical factors always apply. This calculator is an educational reference; all dosing decisions must be confirmed with a qualified prescriber.
Često postavljana pitanja
A Morphine Milligram Equivalent (MME) expresses any opioid's analgesic potency relative to oral morphine. It lets clinicians compare doses across drugs — for example, 10 mg oxycodone (1.5 MME/mg) equals 15 MME, equivalent to 15 mg oral morphine.
Methadone accumulates in body tissues with repeated dosing and its effective half-life lengthens with dose. A low methadone dose is roughly 4× as potent as morphine by weight, but high doses can reach 12×. The CDC step-wise table accounts for this unusual pharmacokinetics.
No — they are clinical approximations based on population-level studies, intended for prescribing oversight rather than precise equianalgesic substitution. Genetic variation, tolerance, renal function, and drug interactions mean actual doses must be adjusted individually.
Poznato i kao
TG we-Calculate Editorial Team. (2026). MME Calculator — Morphine Milligram Equivalents [Online calculator]. TG we-Calculate. https://we-calculate.com/hr/calculator/mme-calculator
TG we-Calculate Editorial Team. "MME Calculator — Morphine Milligram Equivalents." TG we-Calculate. 2026. https://we-calculate.com/hr/calculator/mme-calculator.
TG we-Calculate Editorial Team, "MME Calculator — Morphine Milligram Equivalents," TG we-Calculate, 2026. [Online]. Available: https://we-calculate.com/hr/calculator/mme-calculator
@misc{wecalculate_mme_calculator, title = {MME Calculator — Morphine Milligram Equivalents}, author = {{TG we-Calculate Editorial Team}}, howpublished = {\url{https://we-calculate.com/hr/calculator/mme-calculator}}, year = {2026}, note = {TG we-Calculate} }
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