MME Calculator — Morphine Milligram Equivalents
Convert an opioid dose to morphine milligram equivalents (MME/day) using CDC 2022 clinical conversion factors — helps compare opioid regimens and assess dose against CDC risk thresholds.
Opioid
mg/day
Oral morphine milligram equivalents per day — CDC 2022 factors
- 1
Conversion factor
CDC 2022 factor for Oxycodone = 1.5 MME/mg - 2
MME per day
20 × 1.5 = 30
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MME/day = daily opioid dose × CDC 2022 factor. Key factors: morphine 1.0, oxycodone 1.5, hydromorphone 4.0, tramadol 0.1, fentanyl patch 2.4 per mcg/h, methadone 4–12 (dose-dependent). CDC caution thresholds: 50 MME/day (increased risk) and 90 MME/day (high risk). All dosing decisions must be confirmed with a clinician.
Formula
How this is calculated
Different opioids vary widely in potency. Morphine Milligram Equivalents (MME) create a standardised "common currency" so clinicians can compare doses across agents. The CDC 2022 Clinical Practice Guideline publishes conversion factors — MME per milligram of drug — which this calculator applies: MME/day = daily dose × factor.
For oral morphine the factor is 1.0 by definition; oxycodone is 1.5×; hydromorphone 4.0×; and tramadol only 0.1×. Fentanyl transdermal patches are measured in mcg per hour, not mg per day; the CDC factor of 2.4 MME per mcg/h converts patch strength directly (a 25 mcg/h patch gives 25 × 2.4 = 60 MME/day). Methadone is unique: its potency increases with dose because of tissue accumulation, so the CDC applies a step-wise factor (4 MME/mg for ≤ 20 mg/day, rising to 12 MME/mg for > 60 mg/day).
The risk meter reflects CDC 2022 thresholds: doses above 50 MME/day warrant increased clinical vigilance; above 90 MME/day the CDC recommends careful reassessment of risks and benefits. These are population-level benchmarks, not absolute limits — individual clinical factors always apply. This calculator is an educational reference; all dosing decisions must be confirmed with a qualified prescriber.
Mistoqsijiet frekwenti
A Morphine Milligram Equivalent (MME) expresses any opioid's analgesic potency relative to oral morphine. It lets clinicians compare doses across drugs — for example, 10 mg oxycodone (1.5 MME/mg) equals 15 MME, equivalent to 15 mg oral morphine.
Methadone accumulates in body tissues with repeated dosing and its effective half-life lengthens with dose. A low methadone dose is roughly 4× as potent as morphine by weight, but high doses can reach 12×. The CDC step-wise table accounts for this unusual pharmacokinetics.
No — they are clinical approximations based on population-level studies, intended for prescribing oversight rather than precise equianalgesic substitution. Genetic variation, tolerance, renal function, and drug interactions mean actual doses must be adjusted individually.
Magħruf ukoll bħala
TG we-Calculate Editorial Team. (2026). MME Calculator — Morphine Milligram Equivalents [Online calculator]. TG we-Calculate. https://we-calculate.com/mt/calculator/mme-calculator
TG we-Calculate Editorial Team. "MME Calculator — Morphine Milligram Equivalents." TG we-Calculate. 2026. https://we-calculate.com/mt/calculator/mme-calculator.
TG we-Calculate Editorial Team, "MME Calculator — Morphine Milligram Equivalents," TG we-Calculate, 2026. [Online]. Available: https://we-calculate.com/mt/calculator/mme-calculator
@misc{wecalculate_mme_calculator, title = {MME Calculator — Morphine Milligram Equivalents}, author = {{TG we-Calculate Editorial Team}}, howpublished = {\url{https://we-calculate.com/mt/calculator/mme-calculator}}, year = {2026}, note = {TG we-Calculate} }
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